I rediscovered this paper the other day, as far as I know, one of the first published uses of Python/SciPy for modelling cellular metabolism (a.k.a systems biology). Today it looks trivial but considering the time it was written/published it's not too bad.
Modelling cellular processes with Python and Scipy
BG Olivier, JM Rohwer, JHS Hofmeyr - Molecular biology reports, 2002
Unfortunately, the PDF was published as a bitmap so the next step is to transcribe the code contained in the paper and see if it still works ... reproducible research in the life sciences with a paper over 10 years old? Watch this space ...